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Thefifth-yearresidentsreturnforthefirstdayofayearthatwillmakeorbreaktheircareers:MeredithfacestheconsequencesoftamperingwithDerek’sclinicaltrialandisterminatedatthehospital;ApriltriestostepuptotheplateasChiefResidentinthewakeofagiantsinkholeinthemiddleofSeattle;andCristinaandOwenarestillatoddsovertheirdrasticallydifferentfeelingsfortheirunbornchild.